ZFIN Morpholino: MO1-ptch2

Target Location

Genome Build: GRCz11Chromosome: 2

Genomic Features

No data available

Expression

Gene expression in Wild Types + MO1-ptch2

Expressed Gene	Anatomy	Figures
foxa	anatomical structure central nervous system somite	Fig. EV5 from Pan et al., 2017 Fig. 3 from Zhang et al., 2013
gli1	central nervous system somite	Fig. 4 from Pan et al., 2017
hhip	anatomical structure central nervous system somite	Fig. EV5 from Pan et al., 2017 Fig. 3 from Zhang et al., 2013
myod1	segmental plate adaxial cell somite adaxial cell	Fig. 7 from Woods et al., 2005
nkx2.2b	central nervous system somite	Fig. 4 from Pan et al., 2017

1 - 5 of 9 Show all

Phenotype

Phenotype resulting from MO1-ptch2

Phenotype	Fish	Figures
brain morphology, abnormal	AB + MO1-ptch2	Fig. 7 from Lee et al., 2008
central nervous system nkx2.2b expression increased amount, abnormal	AB + MO1-ptch2	Fig. 4 from Pan et al., 2017
central nervous system gli1 expression increased amount, abnormal	AB + MO1-ptch2	Fig. 4 from Pan et al., 2017
central nervous system hhip expression increased amount, abnormal	AB + MO1-ptch2	Fig. EV5 from Pan et al., 2017
central nervous system foxa expression increased amount, abnormal	AB + MO1-ptch2	Fig. EV5 from Pan et al., 2017

1 - 5 of 24 Show all

Phenotype of all Fish created by or utilizing MO1-ptch2

Phenotype	Fish	Conditions	Figures
eye mislocalised medially, abnormal	AB + MO1-ptch2	standard conditions	Fig. 7 from Lee et al., 2008
somite muscle pioneer increased amount, abnormal	AB + MO1-ptch2	standard conditions	Fig. 4 from Pan et al., 2017 Fig. S10 from Wilson et al., 2009
somite foxa expression increased amount, abnormal	AB + MO1-ptch2	standard conditions	Fig. EV5 from Pan et al., 2017
brain morphology, abnormal	AB + MO1-ptch2	standard conditions	Fig. 7 from Lee et al., 2008
lens displaced, abnormal	AB + MO1-ptch2	standard conditions	Fig. 7 from Lee et al., 2008

1 - 5 of 45 Show all

Citations

Include unpublished citations

Hong, S., Hu, P., Jang, J.H., Carrington, B., Sood, R., Berger, S.I., Roessler, E., Muenke, M. (2020) Functional analysis of Sonic Hedgehog variants associated with holoprosencephaly in humans using a CRISPR/Cas9 zebrafish model. Human Mutation. 41(12):2155-2166
Nagai-Tanima, M., Hong, S., Hu, P., Carrington, B., Sood, R., Roessler, E., Muenke, M. (2020) Rare hypomorphic human variation in the heptahelical domain of SMO contributes to holoprosencephaly phenotypes. Human Mutation. 41(12):2105-2118
Pan, C., Xiong, Y., Lv, X., Xia, Y., Zhang, S., Chen, H., Fan, J., Wu, W., Liu, F., Wu, H., Zhou, Z., Zhang, L., Zhao, Y. (2017) UbcD1 regulates Hedgehog signaling by directly modulating Ci ubiquitination and processing. EMBO reports. 18:1922-1934
Zhang, Z., Feng, J., Pan, C., Lv, X., Wu, W., Zhou, Z., Liu, F., Zhang, L., and Zhao, Y. (2013) Atrophin-Rpd3 complex represses Hedgehog signaling by acting as a corepressor of CiR. The Journal of cell biology. 203(4):575-583
Stückemann, T., Wegleiter, T., Stefan, E., Nägele, O., Tarbashevich, K., Böck, G., Raz, E., and Aanstad, P. (2012) Zebrafish Cxcr4a determines the proliferative response to Hedgehog signalling. Development (Cambridge, England). 139(15):2711-2720
Wilson, C.W., Nguyen, C.T., Chen, M.H., Yang, J.H., Gacayan, R., Huang, J., Chen, J.N., and Chuang, P.T. (2009) Fused has evolved divergent roles in vertebrate Hedgehog signalling and motile ciliogenesis. Nature. 459(7243):98-102
Lee, J., Willer, J.R., Willer, G.B., Smith, K., Gregg, R.G., and Gross, J.M. (2008) Zebrafish blowout provides genetic evidence for Patched1-mediated negative regulation of Hedgehog signaling within the proximal optic vesicle of the vertebrate eye. Developmental Biology. 319(1):10-22
Beales, P.L., Bland, E., Tobin, J.L., Bacchelli, C., Tuysuz, B., Hill, J., Rix, S., Pearson, C.G., Kai, M., Hartley, J., Johnson, C., Irving, M., Elcioglu, N., Winey, M., Tada, M., and Scambler, P.J. (2007) IFT80, which encodes a conserved intraflagellar transport protein, is mutated in Jeune asphyxiating thoracic dystrophy. Nature Genetics. 39(6):727-729
Cerda, G.A., Thomas, J.E., Allende, M.L., Karlstrom, R.O., and Palma, V. (2006) Electroporation of DNA, RNA, and morpholinos into zebrafish embryos. Methods (San Diego, Calif.). 39(3):207-211
Ochi, H., Pearson, B.J., Chuang, P.T., Hammerschmidt, M., and Westerfield, M. (2006) Hhip regulates zebrafish muscle development by both sequestering Hedgehog and modulating localization of Smoothened. Developmental Biology. 297(1):127-140

1 - 10 of 12

Show