miRNA Gene
mir140
- ID
- ZDB-MIRNAG-081006-2
- Name
- microRNA 140
- Symbol
- mir140 Nomenclature History
- Previous Names
- Type
- miRNA_gene
- Location
- Chr: 25 Mapping Details/Browsers
- Description
- Acts upstream of or within embryonic viscerocranium morphogenesis; negative regulation of gene expression; and roof of mouth development. Located in cytoplasm and nucleus. Is expressed in several structures, including fin; gonad; head; heart; and pectoral fin bud. Human ortholog(s) of this gene implicated in spondyloepiphyseal dysplasia Nishimura type. Orthologous to human MIR140 (microRNA 140).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 6 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Eberhart et al., 2008
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| spondyloepiphyseal dysplasia Nishimura type | Alliance | Spondyloepiphyseal dysplasia, Nishimura type | 618618 |
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Domain, Family, and Site Summary
No data available
Domain Details Per Protein
No data available
- Genome Browsers
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
mir140-201
(1)
|
Ensembl | 105 nt | ||
| miRNA | mir140-001 (1) | 22 nt | |||
| miRNA | mir140*-002 (1) | 23 nt |
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Interactions and Pathways
No data available
Plasmids
No data available
- Zebrafish Nomenclature Committee (2024) Nomenclature Data Curation (2024). Nomenclature Committee Submission.
- Desvignes, T., Bardou, P., Montfort, J., Sydes, J., Guyomar, C., George, S., Postlethwait, J.H., Bobe, J. (2022) FishmiRNA: An evolutionarily supported microRNA annotation and expression database for ray-finned fishes. Molecular Biology and Evolution. 39(2)
- Zhang, X., Yang, F., Liu, F., Tian, Q., Hu, M., Li, P., Zeng, Y. (2022) Conservation of Differential Animal MicroRNA Processing by Drosha and Dicer. Frontiers in molecular biosciences. 8:730006
- Zhang, X., Li, Y., Zhang, Y., Li, S. (2021) Characterization of small RNAs in early zebrafish PGCs. Acta biochimica et biophysica Sinica. 53(4):514-516
- Ikert, H., Craig, P.M. (2019) Chronic exposure to venlafaxine and increased water temperature reversibly alters microRNA in zebrafish gonads (Danio rerio). Comparative biochemistry and physiology. Part D, Genomics & proteomics. 33:100634
- Lopez-Baez, J.C., Simpson, D.J., LLeras Forero, L., Zeng, Z., Brunsdon, H., Salzano, A., Brombin, A., Wyatt, C., Rybski, W., Huitema, L.F.A., Dale, R.M., Kawakami, K., Englert, C., Chandra, T., Schulte-Merker, S., Hastie, N.D., Patton, E.E. (2018) Wilms Tumor 1b defines a wound-specific sheath cell subpopulation associated with notochord repair.. eLIFE. 7
- Schoen, C., Aschrafi, A., Thonissen, M., Poelmans, G., Von den Hoff, J.W., Carels, C.E.L. (2017) MicroRNAs in Palatogenesis and Cleft Palate. Frontiers in Physiology. 8:165
- Gan, S., Huang, Z., Liu, N., Su, R., Xie, G., Zhong, B., Zhang, K., Wang, S., Hu, X., Zhang, J., Xiang, S. (2016) MicroRNA-140-5p impairs zebrafish embryonic bone development via targeting BMP-2. FEBS letters. 590(10):1438-46
- Khayrullin, A., Smith, L., Mistry, D., Dukes, A., Pan, Y.A., Hamrick, M.W. (2016) Chronic alcohol exposure induces muscle atrophy (myopathy) in zebrafish and alters the expression of microRNAs targeting the Notch pathway in skeletal muscle. Biochemical and Biophysical Research Communications. 479(3):590-595
- Khor, E.S., Noor, S.M., Wong, P.F. (2016) Expression of zTOR-associated microRNAs in zebrafish embryo treated with rapamycin. Life sciences. 150:67-75
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