ZFIN Lab: Philipp Lab

ZFIN ID: ZDB-LAB-240611-1

Philipp Lab

PI/Director:	Philipp, Melanie
Co-PI / Senior Researcher:	Burkhalter, Martin
Contact Person:	Philipp, Melanie
Email:	sekretariat-pg@medizin.uni-tuebingen.de
URL:	https://www.medizin.uni-tuebingen.de/de/das-klinikum/einrichtungen/institute/pharmakologie-und-pharmakogenomik/pharmakogenomik/forschung/ag-philipp
Address:	University of Tuebingen Department of Experimental and Clinical Pharmacology and Pharmacogenomics Division of Pharmacogenomics Wilhelmstrasse 45 72074 Tuebingen Germany
Country:	Germany
Phone:	+49 7071 29 73082
Fax:	+49 7071 29 35286
Line Designation:	tbz

GENOMIC FEATURES ORIGINATING FROM THIS LAB

Show all 1 genomic features

STATEMENT OF RESEARCH INTERESTS

The Philipp lab investigates the molecular causes of congenital malformations such as heart defects, heterotaxy and microcephaly. We are interested in how the cellular signaling changes depending on certain gene variants and how the resulting clinical manifestations could be ameliorated. Particular interest lies on GPCR kinases, replication proteins and cilia-related alterations.

LAB MEMBERS

Duong Phu, Max Graduate Student	Guerrero Samandis, Alessandra Graduate Student	Sailer, Steffen Graduate Student
Vu, Anna Graduate Student

ZEBRAFISH PUBLICATIONS OF LAB MEMBERS

Gerhards, J., Maerz, L.D., Matthees, E.S.F., Donow, C., Moepps, B., Premont, R.T., Burkhalter, M.D., Hoffmann, C., Philipp, M. (2023) Kinase Activity Is Not Required for G Protein-Coupled Receptor Kinase 4 Restraining mTOR Signaling during Cilia and Kidney Development. Journal of the American Society of Nephrology : JASN. 34(4):590-606

Dutto, I., Gerhards, J., Herrera, A., Souckova, O., Škopová, V., Smak, J., Junza, A., Yanes, O., Boeckx, C., Burkhalter, M.D., Zikánová, M., Pons, S., Philipp, M., Lüders, J., Stracker, T.H. (2022) Pathway specific effects of ADSL deficiency on neurodevelopment. eLIFE. 11:

Heigwer, J., Kutzner, J., Haeussler, M., Burkhalter, M.D., Draebing, T., Juergensen, L., Katus, H.A., Philipp, M., Westhoff, J.H., Hassel, D. (2020) miR-103/107 regulates left-right asymmetry in zebrafish by modulating Kupffer's vesicle development and ciliogenesis. Biochemical and Biophysical Research Communications. 527(2):432-439

Burczyk, M.S., Burkhalter, M.D., Tena, T.C., Grisanti, L.A., Kauk, M., Matysik, S., Donow, C., Kustermann, M., Rothe, M., Cui, Y., Raad, F., Laue, S., Moretti, A., Zimmermann, W.H., Wess, J., Kühl, M., Hoffmann, C., Tilley, D.G., Philipp, M. (2019) Muscarinic receptors promote pacemaker fate at the expense of secondary conduction system tissue in zebrafish. JCI insight. 4(20):

Halder, S., Torrecilla, I., Burkhalter, M.D., Popović, M., Fielden, J., Vaz, B., Oehler, J., Pilger, D., Lessel, D., Wiseman, K., Singh, A.N., Vendrell, I., Fischer, R., Philipp, M., Ramadan, K. (2019) SPRTN protease and checkpoint kinase 1 cross-activation loop safeguards DNA replication. Nature communications. 10:3142

Burkhalter, M.D., Sridhar, A., Sampaio, P., Jacinto, R., Burczyk, M.S., Donow, C., Angenendt, M., Investigators, C.N.F.C.H.D., Hempel, M., Walther, P., Pennekamp, P., Omran, H., Lopes, S.S., Ware, S.M., Philipp, M. (2019) Imbalanced mitochondrial function provokes heterotaxy via aberrant ciliogenesis. The Journal of Clinical Investigation. 130:2841-2855

Maerz, L.D., Burkhalter, M.D., Schilpp, C., Wittekindt, O.H., Frick, M., Philipp, M. (2019) Pharmacological cholesterol depletion disturbs ciliogenesis and ciliary function in developing zebrafish. Communications biology. 2:31

Maerz, L.D., Casar Tena, T., Gerhards, J., Donow, C., Jeggo, P.A., Philipp, M. (2019) Analysis of cilia dysfunction phenotypes in zebrafish embryos depleted of Origin recognition complex factors. European journal of human genetics : EJHG. 27(5):772-782

Casar Tena, T., Maerz, L.D., Szafranski, K., Groth, M., Blätte, T.J., Donow, C., Matysik, S., Walther, P., Jeggo, P.A., Burkhalter, M.D., Philipp, M. (2018) Resting cells rely on the DNA helicase component MCM2 to build cilia. Nucleic acids research. 47(1):134-151

Ogungbenro, Y.A., Tena, T.C., Gaboriau, D., Lalor, P., Dockery, P., Philipp, M., Morrison, C.G. (2018) Centrobin controls primary ciliogenesis in vertebrates. The Journal of cell biology. 217(4):1205-1215

Hempel, M., Casar Tena, T., Diehl, T., Burczyk, M.S., Strom, T.M., Kubisch, C., Philipp, M., Lessel, D. (2017) Compound heterozygous GATA5 mutations in a girl with hydrops fetalis, congenital heart defects and genital anomalies. Human genetics. 136(3):339-346

Lessel, D., Muhammad, T., Casar Tena, T., Moepps, B., Burkhalter, M.D., Hitz, M.P., Toka, O., Rentzsch, A., Schubert, S., Schalinski, A., Bauer, U.M., Kubisch, C., Ware, S.M., Philipp, M. (2016) The analysis of heterotaxy patients reveals new loss-of-function variants of GRK5. Scientific Reports. 6:33231

Stiff, T., Casar Tena, T., O'Driscoll, M., Jeggo, P.A., Philipp, M. (2016) ATR promotes cilia signalling; links to developmental impacts. Human molecular genetics. 25(8):1574-87

Tena, T.C., Philipp, M. (2016) Assessing Smoothened-mediated Hedgehog signaling in zebrafish. Methods in cell biology. 132:147-64

Burczyk, M.S., Burkhalter, M.D., Blätte, T., Matysik, S., Caron, M.G., Barak, L.S., Philipp, M. (2015) Phenotypic Regulation of the Sphingosine 1-Phosphate Receptor Miles Apart by G Protein-Coupled Receptor Kinase 2. Biochemistry. 54(3):765-75

Lessel, D., Vaz, B., Halder, S., Lockhart, P.J., Marinovic-Terzic, I., Lopez-Mosqueda, J., Philipp, M., Sim, J.C., Smith, K.R., Oehler, J., Cabrera, E., Freire, R., Pope, K., Nahid, A., Norris, F., Leventer, R.J., Delatycki, M.B., Barbi, G., von Ameln, S., Högel, J., Degoricija, M., Fertig, R., Burkhalter, M.D., Hofmann, K., Thiele, H., Altmüller, J., Nürnberg, G., Nürnberg, P., Bahlo, M., Martin, G.M., Aalfs, C.M., Oshima, J., Terzic, J., Amor, D.J., Dikic, I., Ramadan, K., Kubisch, C. (2014) Mutations in SPRTN cause early onset hepatocellular carcinoma, genomic instability and progeroid features. Nature Genetics. 46:1239-44

Philipp, M., Berger, I.M., Just, S., Caron, M.G. (2014) Overlapping and Opposing Functions of GRK2 and GRK5 during Heart Development. The Journal of biological chemistry. 289(38):26119-30

Burkhalter, M.D., Fralish, G.B., Premont, R.T., Caron, M.G., and Philipp, M. (2013) Grk5l Controls Heart Development by Limiting mTOR Signaling during Symmetry Breaking. Cell Reports. 4(4):625-632

Schuff, M., Siegel, D., Philipp, M., Bundschu,. K., Heymann, N., Donow, C., and Knöchel, W. (2012) Characterization of Danio rerio Nanog and Functional Comparison to Xenopus Vents. Stem cells and development. 21(8):1225-1238

Evron, T., Philipp, M., Lu, J., Meloni, A.R., Burkhalter, M., Chen, W., and Caron, M.G. (2011) Growth arrest Specific 8 (Gas8) and GPCR kinase 2 (GRK2) cooperate in the control of smoothened signaling. The Journal of biological chemistry. 286(31):27676-86

Soderblom, E.J., Philipp, M., Thompson, J.W., Caron, M.G., and Moseley, M.A. (2011) Quantitative label-free phosphoproteomics strategy for multifaceted experimental designs. Analytical chemistry. 83(10):3758-3764

Chen, M., Philipp, M., Wang, J., Premont, R.T., Garrison, T.R., Caron, M.G., Lefkowitz, R.J., and Chen, W. (2009) G protein-coupled receptor kinases phosphorylate LRP6 in the Wnt pathway. The Journal of biological chemistry. 284(50):35040-35048

Philipp, M., Fralish, G.B., Meloni, A.R., Chen, W., Macinnes, A., Barak, L.S., and Caron, M.G. (2008) Smoothened Signaling in Vertebrates Is Facilitated by a G-Protein Coupled Receptor Kinase. Molecular biology of the cell. 19(12):5478-5489