Lab
Internal Medicinte, section Endocrinology
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Statement of Research Interest
Phaeochromocytoma, paraganglioma: endocrine tumours.
Phaeochromocytomas or paragangliomas (PPGLs) are chromaffin-cell tumours arising from the adrenal medulla and extra-adrenal paraganglia. PPGLs caused by mutations in the B-subunit of the succinate dehydrogenase (SDHB) have the highest metastatic rate among PPGLs, and effective systemic therapy is lacking. To unravel underlying pathogenic mechanisms, and to evaluate therapeutic strategies, suitable in vivo models are needed. For this we use the zebrafish model to study the metabolic effects of sdhb disruption during different developmental stages and develop screening assays to identify novel therapeutic targets in vivo. Besides oncological syndromes, our model might also be useful for pediatric mitochondrial diseases caused by loss of the SDHB gene.
Phaeochromocytomas or paragangliomas (PPGLs) are chromaffin-cell tumours arising from the adrenal medulla and extra-adrenal paraganglia. PPGLs caused by mutations in the B-subunit of the succinate dehydrogenase (SDHB) have the highest metastatic rate among PPGLs, and effective systemic therapy is lacking. To unravel underlying pathogenic mechanisms, and to evaluate therapeutic strategies, suitable in vivo models are needed. For this we use the zebrafish model to study the metabolic effects of sdhb disruption during different developmental stages and develop screening assays to identify novel therapeutic targets in vivo. Besides oncological syndromes, our model might also be useful for pediatric mitochondrial diseases caused by loss of the SDHB gene.
Lab Members
| Dona, Margo Post-Doc |