Lab
Qiang Wang Lab
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Statement of Research Interest
The basic body plan of vertebrate embryos is established during embryo morphogenesis. How a relatively uniform embryo becomes asymmetric at the early developmental stages? This asymmetry consists of two aspects, the initial cell fate decision and the embryonic body patterning that establishes the dorsal-ventral, anterior-posterior, and left-right axes. Understanding the underlying molecular genetic mechanisms of these morphogenetic processes is one of the central goals of developmental biology. The function of genes and signal pathways, such as TGF-β, BMP and Wnt, are being studied in zebrafish embryos and mammalian cell lines using genetic, biochemical and molecular approaches. Research progresses on the great mysteries during embryo morphogenesis will help us to get a better understanding of how a fertilized egg gives rise to a live baby.
Lab Members
- Wang, W., Yang, N., Wang, L., Zhu, Y., Chu, X., Xu, W., Li, Y., Xu, Y., Gao, L., Zhang, B., Zhang, G., Sun, Q., Wang, W., Wang, Q., Zhang, W., Chen, D. (2024) The TET-Sall4-BMP regulatory axis controls craniofacial cartilage development. Cell Reports. 43:113873113873
- Zhao, S., Mo, G., Wang, Q., Xu, J., Yu, S., Huang, Z., Liu, W., Zhang, W. (2024) Role of RB1 in neurodegenerative diseases: inhibition of post-mitotic neuronal apoptosis via Kmt5b. Cell death discovery. 10:182182
- Zhao, S., Wang, C., Luo, H., Li, F., Wang, Q., Xu, J., Huang, Z., Liu, W., Zhang, W. (2024) A role for Retinoblastoma 1 in hindbrain morphogenesis by regulating GBX family. Journal of genetics and genomics = Yi chuan xue bao. 51(9):900-910
- Mao, A., Li, Z., Ning, G., Zhou, Z., Wei, C., Li, J., He, X., Wang, Q. (2023) Sclerotome-derived PDGF signaling functions as a niche cue responsible for primitive erythropoiesis. Development (Cambridge, England). 150(22):
- Sun, W., Wang, M., Zhao, J., Zhao, S., Zhu, W., Wu, X., Li, F., Liu, W., Wang, Z., Gao, M., Zhang, Y., Xu, J., Zhang, M., Wang, Q., Wen, Z., Shen, J., Zhang, W., Huang, Z. (2023) Sulindac selectively induces autophagic apoptosis of GABAergic neurons and alters motor behaviour in zebrafish. Nature communications. 14:53515351
- Li, Y., Ning, G., Kang, B., Zhu, J., Wang, X.Y., Wang, Q., Cai, T. (2022) A novel recessive mutation in OXR1 is identified in patient with hearing loss recapitulated by the knockdown zebrafish. Human molecular genetics. 32(5):764-772
- Liu, J., Zhang, M., Dong, H., Liu, J., Mao, A., Ning, G., Cao, Y., Zhang, Y., Wang, Q. (2022) Chemokine signaling synchronizes angioblast proliferation and differentiation during pharyngeal arch artery vasculogenesis. Development (Cambridge, England). 149(23):
- Yan, H., Yang, S., Hou, Y., Ali, S., Escobar, A., Gao, K., Duan, R., Kubisiak, T., Wang, J., Zhang, Y., Xiao, J., Jiang, Y., Zhang, T., Wu, Y., Burmeister, M., Wang, Q., Cuajungco, M.P., Wang, J. (2022) Functional Study of TMEM163 Gene Variants Associated with Hypomyelination Leukodystrophy. Cells. 11(8):
- Yang, S., Ning, G., Hou, Y., Cao, Y., Xu, J., Wu, J., Zhang, T., Wang, Q. (2022) Myoneurin regulates BMP signaling by competing with Ppm1a for Smad binding. iScience. 25:104495
- Jiang, J., Chen, L., Wu, S., Lv, L., Liu, X., Wang, Q., Zhao, X. (2020) Effects of difenoconazole on hepatotoxicity, lipid metabolism and gut microbiota in zebrafish (Danio rerio). Environmental pollution (Barking, Essex : 1987). 265:114844
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