ZFIN Image: Jiang et al., 2024, Fig 8

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Figure Caption

Fig 8 Model

RA signaling induces the transcription of rcan2, an endogenous inhibitor of calcineurin, to alleviate calcineurin inhibition of Kcnk5b channel activity. Kcnk5b decreases intracellular K⁺ levels in the mesenchyme that increase depolarization to promote IP₃R-mediated Ca²⁺ release from the ER. The increase in intracellular Ca²⁺ activates CaMKK, and both are required for the increased transcription of shha and enhanced growth of the pectoral fin buds by Kcnk5b. ER, endoplasmic reticulum; RA, retinoic acid.

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