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Fig. 1 Charts (left) show the actograms of locomotor activity of wild-type (WT) (top) and asip1-Tg (bottom) animals maintained under a constant LD photoperiod for 28 days. Subsequently, the LD cycle was inverted (DL) and locomotor activity screened for 12 days. Actograms are presented in a dual-plot format (48 h time scale) to facilitate visualisation. Horizontal bars at the bottom represent periods of daylight (in white) and night (in black) for 2 consecutive days. The x-axes indicate time of day (h) and y-axes indicate time (days). Charts (right) show periodogram analysis providing the periodicity of the data with tau values close to 1440 m (24 h) for WT animals under LD and DL. No periodicity was detected in asip1-Tg animals.