Fig. 7

Fig. 7

Axon regeneration induced by her6^−/− promotes recovery of motor function in zebrafish. a Diagram of the equipment to introduce and record the escape response. b Representative images of the initial position and maximal turn angle position from the control and her6^−/− zebrafish larvae in the uninjured and injured groups. The red line represents the direction of the current position. θ represents the maximal angle of rotation of the head. scale bar, 1 mm. c A series of images of escape response in the control and her6^−/− zebrafish larvae in the uninjured and injured groups. Time after the escape response (in milliseconds) is given in each frame. * represents the time for the maximum turning angle scale bar, 1 mm. d The maximum turn angle of escape in the her6^−/− larvae was significantly higher than that in the control group after injury. (control + uninjured: 131.8 ± 9.591°, n = 9 fish; her6^−/− + uninjured: 136.2 ± 5.193°, n = 9 fish; control + injured: 90.8 ± 2.569°, n = 8 fish; her6^−/− + injured: 116.7 ± 4.823°, n = 7 fish). Assessed by one-way ANOVA. e The time required to reach the maximum turning angle in the her6^−/− larvae was significantly shorter than that in the control group after injury. (control + uninjured: 9.778 ± 0.9969 ms, n = 9 fish; her6^−/− + uninjured: 10.78 ± 1.4320 ms, n = 9 fish; control + injured: 18.25 ± 0.5261 ms, n = 8 fish; her6^−/− + injured: 13.41 ± 0.5281 ms, n = 7 fish). Assessed by one-way ANOVA