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Fig. 10 Complex 6 inhibits VEGFA and BMP signaling-associated gene expression in a dose-dependent manner in zebrafish embryos. (a) Schematic of the experimental procedure. (b) qPCR analysis of vegfaa, vegfab, ccnd1, ccnd2a, ccnd2b, and etv2 in the vehicle and complex 6-treated 72 hpf embryos (n = 4). (c) qPCR analysis of bmp2b, bmp4, bmp7a, and id2a in the vehicle and 6-treated 72 hpf embryos (n = 4). In parts (b) and (c), data are the mean ± SEM. Mean Ct values are presented in Table S3.
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Full text @ J. Med. Chem.