ZFIN Image: Sun et al., 2023, Fig. 6

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Figure Caption

Fig. 6 Mechanisms of disorders in lipid metabolism after 72 hpe exposure of PFOA and alternatives in zebrafish. As shown in the figure, activation of PPARα by PFOA and alternatives as exogenous ligands, promoting significant changes in target genes related to lipid metabolism downstream of PPARα; Similarly, PFOA and alternatives promote the maturation of SREBP into the nucleus, causing significant changes in target genes related to lipid metabolism downstream of SREBP. Lipid metabolism catabolism, anabolism is significantly upregulated, disrupting the balance of lipid metabolism and causing lipid retention; Sterol transport related factors npc1l1, abcg1 and yjefn3 (aibp) also changed significantly, which further disturbed the lipid metabolism balance in zebrafish.

Acknowledgments

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