Fig. 4

Photic stimulation elicits elevated neural responses with fast dynamics and prominent depressed state. (A) Mean neural calcium response (relative change in fluorescence [ΔF/F; %]) to photic stimulation per subgroup averaged across five trials of 5‐min interstimulus interval. Gray shaded area indicates photic stimulation. (B) Latency to peak amplitude during 10‐s photic stimulation. (C) Peak amplitude during photic stimulation. (D) Time constant for 50% decay of calcium signal from light offset. (E) Elevated state as measured by mean area under the curve above 2 SD from a 1‐min baseline (1 min period after light onset). (F) Depressed state as measured by mean area over the curve below 2 SD from a 1‐min baseline (first 2 min after light turned off). Total sample size for pentylenetetrazole (PTZ) model: control, n = 8; 1 mmol·L⁻¹, n = 7; 5 mmol·L⁻¹, n = 9; 15 mmol·L⁻¹, n = 10; for gabra1 model: wild‐type (wt), n = 9; heterozygous (het), n = 13; homozygous (hom), n = 9; for eaat2a model: wt, n = 7; het, n = 13; hom, n = 11. For eaat2a hom mutants, four of 11 animals had only plateaulike events; hence, seven animals were included in the analyses for this figure. *p < .05, **p < .01 by Wilcoxon rank‐sum test. Shaded regions of individual colors represent SEM of each group. Boxplots represent median with interquartile ranges; whiskers extend to the most extreme data points that are not outliers