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Figure 5
Proposed mechanism by which E2 signaling contributes to nephron segmentation. When E2 signaling is active (left), E2 diffuses from the yolk into the neighboring intermediate mesoderm (IM) cells. E2 binds to Esr2b, which activates irx3b and irx1a, ultimately resulting in balanced DE and DL fate. When E2 signaling is inactive (right) via morpholino knockdown or chemical inhibition by PHTPP, esr2b activity is diminished, as well as expression of downstream targets irx3b and irx1a, resulting in favored DL fate.
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