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Fig 10
Hypothetical model on roles of oocyte-derived GDF9 (gdf9) in controlling zebrafish folliculogenesis.
(A) Intrafollicular distribution of GDF9 and other important genes (fshr, lhcgr, cyp19a1a, inhbaa/ab, inhbb, inha, acvr1b, acvr2a/b and smad2/3/3/7). (B) GDF9 from the oocyte plays an important gating role in controlling zebrafish follicle activation or PG-PV transition and therefore puberty onset. PV-I, early PV with one single layer of small cortical alveoli; PV-II, mid-PV with one single layer of large cortical alveoli; PV-III, late PV with multiple layers of cortical alveoli.
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