ZFIN Image: Sarvari et al., 2021, Fig. 3

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Figure Caption

Fig. 3 The endocardium is affected in rbx1 mutants

(A-H′) 3D Confocal images (maximum intensity projections) (A–H), and 2D mid-sagittal sections (A′-H′) of the endocardium from rbx1 animals. (A-F′) Endocardial morphology in rbx1^+/+ and rbx1^−/− siblings at 60 (A-B′), 72 (C-D′) and 80 (E-F′) hpf. At 72 hpf a minor reduction in ventricular size is visible in rbx1 mutants (C-D′). At 80 hpf, rbx1 mutants exhibit a smaller ventricle with a stretched AV canal and outflow tract (E-F′). (G-H′) Endocardial morphology in rbx1^+/+ (G-G′) and rbx1^−/− (H–H′) siblings at 102 hpf. rbx1^−/− larvae exhibit a smaller ventricle (H–H′) compared with rbx1^+/+ (G-G′) siblings.

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Acknowledgments

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Reprinted from Developmental Biology, 480, Sarvari, P., Rasouli, S.J., Allanki, S., Stone, O.A., Sokol, A., Graumann, J., Stainier, D.Y.R., The E3 ubiquitin-protein ligase Rbx1 regulates cardiac wall morphogenesis in zebrafish, 1-12, Copyright (2021) with permission from Elsevier. Full text @ Dev. Biol.