ZFIN Image: Edirisinghe et al., 2022, Figure 4

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Figure 4

PDRN effect on goblet cell characteristics in the corneal epithelium following the cornea injury and PDRN treatment. (A) Magnified transverse sections stained with PAS showing the representative panoramic overview of three corneal epithelial zones (dorsal peripherals, central, and ventral peripheral) and matured goblet cells at 72 hpi after the cornea injury (Scale bars, 200 μm). (B) Images showing the mature goblet cells (red square) in the PDRN-treated group, and (C) magnified zones showing that the epithelium cells are not well attached (black arrowheads) in the cornea- injured vehicle-treated group. The graphs illustrate quantification of (D) goblet cell density and (E) the goblet cell surface area (an indicator of size) following the cornea injury at 72 hpi. Goblet cell density was measured as the number of cells/mm of corneal surface (one-way ANOVA was performed to find statistical significance; * p < 0.05, n = 8).

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Acknowledgments

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