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Fig. 7
Tnks inhibition protects against cardiac dysfunction and ventricle dilatation induced by ISO in adult zebrafish. (A–C) Echocardiography depicts restored systolic function upon XAV939 treatment in ISO-treated hearts as determined by the ejection fraction (A), fractional shortening (B) and fractional area change (C). (D–F) Representative LAX images of adult zebrafish that received vehicle (D), ISO (E), or ISO and XAV939 (F) for 7 days. V: ventricle outlined in red, anterior to the left. (G,H) XAV939 treatment prevents ventricular dilatation as depicted by the preserved end-systolic (G) and end-diastolic (H) areas. (I) Heart rate displays no significant difference between the groups. Vehicle, n = 32; ISO, n = 23; ISO+XAV939, n = 10. Data are presented as mean ± SD. One-way ANOVA with Tukey adjustment for multiple comparisons: * p < 0.05, ** p < 0.01, *** p < 0.001.