ZFIN Image: Verwilligen et al., 2022, Fig. 2

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Fig. 2

Fig. 2. Absence of scavenger receptors stab1 and stab2 reduces ApoB containing lipoprotein clearance by endothelial cells.

(A–C) Uptake of lipoproteins by endothelial cells and macrophages in 3dpf ABTL and stab1^−/−stab2^−/− mpeg1:rfp transgenic zebrafish at 3 h post injection (hpi) ((ox)LDL) or 24 hpi (HDL) and the quantification of co-localization events between lipoproteins (green) and macrophages (purple) after 1 hpi (n = 9), 3 hpi (n = 6) or 24 hpi (n = 10). (D) Overview of possible mechanisms regarding cellular cholesterol uptake in ABTL and stab1^−/−stab2^−/−. Means ± SEM; p < 0.01**; p < 0.001***. Magnification: 10× and 40×. (For interpretation of the references to color in this figure legend, the reader is referred to the Web version of this article.)

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Acknowledgments

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