Figure 2

Figure 2

Conserved synteny analysis of slc5a gene family members in the NIS clade. (a, c, e, g, i) Ortholog comparison plots for human (Hsa, top), gar (Loc, middle), and stickleback (Gac, bottom). Red lines link orthologous slc5a family members. (b, d, f, h, j) Dot‐plot analyses showing a human chromosome on the horizontal axis with the location of its SLC5A gene marked; stickleback orthologs and close paralogs of human genes are displayed directly above the location of the human gene on a row indicating the chromosome on which the stickleback gene resides. For example, “b” shows the SLC5A5 gene on human chromosome 19 and indicates its ortholog on stickleback linkage group GacVIII. Gene order in the horizontal dimension is that of the human chromosome. Chromosome regions that appear in duplicate due to the teleost genome duplication event are evident. (k) Dot plot of Hsa2 paralogs on other human chromosomes showing the location of NIS‐clade genes in paralogons. (l) Dot plot of Hsa22 paralogs on other human chromosomes showing the location of SGLT‐clade genes in paralogons