Fig. 6

Fig. 6

Rbpr2 is critical for photoreceptor cell viability and visual function under dietary vitamin A restriction. (A) OCT retinal analysis of 12-week old controls (WT, Rbpr2^fl/fl) and homozygous Rbpr2^−/− mice on vitamin A-deficient diets. Note that the photoreceptor cell layer is reduced (p < 0.05) in Rbpr2^−/− mice compared to controls. (B) Fundus imaging of 12-week old wild-type (WT), floxed (Rbpr2^fl/fl), and homozygous (Rbpr2^−/−) mice after intraperitoneal injection with ICG (15 mg/kg, Acros Organics, NJ, USA). Note that blood vessel leakage was observed in Rbpr2^−/− mice compared to controls. (C–F) Scotopic electroretinograms of 12-week old control (Rbpr2^fl/fl) and Rbpr2^−/− mice on vitamin A-deficient diets, Rbpr2^−/− vs. controls at 0.1 cds/m².