ZFIN Image: America et al., 2022, Fig. 7

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Figure Caption

Fig. 7 Figure 7. Functional comparison of mouse and zebrafish Gpr124 extracellular and transmembrane domains (A and D) Schematics of the investigated mouse and zebrafish Gpr124 chimeras. (B and E) Luciferase dose-response assays in HEK293 STF cells co-transfected with Wnt7a, Fz1, Reck, and the indicated Gpr124 chimeras. Data are normalized to ELISA data, n = 3. (C and F) Quantification of hindbrain CtAs in 48 hpf gpr124 morphant embryos injected at the one-cell stage with 100 pg of the indicated mRNAs. (G) Model for the various modalities of Gpr124/Reck-dependent Wnt7a/b signaling and the importance of their relative contribution in different species. Related to Figures S5 and S6.

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Acknowledgments

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