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Fig. 3
Abnormal morphologic characteristics of RPE cells in cyp4v7/cyp4v8 DKO zebrafish. (A) Immunofluorescence analysis of flat-mounted eyecups from WT and cyp4v7−/−cyp4v8−/− zebrafish at 7, 10, 12, and 20 months after fertilization using the anti-ZO-1 antibody. We defined the loss of hexagonal cellular architecture and junctional integrity cells as abnormal RPE cells. White arrows indicate the abnormal RPE cells. Scale bar: 20 µm. (B) The numbers of abnormal RPE cells were quantified for each of the images. The results are shown as mean ± SD. ***P < 0.001; **P < 0.01; *P < 0.05.
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Full text @ Invest. Ophthalmol. Vis. Sci.