Fig. 3

Differential RNA-splicing and protein-protein interactions associated with cancer and metastasis were enriched in the F1 and F2 populations compared to parental population. a A volcano plot of the 526 differentially spliced transcripts. b Overall, 43 genes were both significantly differentially expressed and differentially spliced. c Gene-disease association analysis using DisGeNET revealed differentially spliced genes associated with mammary neoplasms. d KEGG pathway analysis identified differentially spliced genes included within the Pathways in Cancer geneset. e BIRC5 was one of the few genes that was both differentially expressed and differentially spliced. The three spliced variants of BIRC5 differentially spliced in the F1 and F2 populations are shown