ZFIN Image: Reuter et al., 2022, Fig 4

Image

Figure Caption

Fig 4 Neurod1 contains a domain evolutionarily conserved in all vertebrate Neurod family members.

Upper part: Schematic representation of dr-Neurod1 showing the 12aa basic domain (b), the 45aa helix-loop-helix (HLH) domain, the 41aa evolutionary conserved domain (ECD) and the two transactivation domains (AD1 and AD2). Lower part: Alignment of vertebrate Neurod proteins highlighting the ECD and the 19aa ultra conserved elements (UCE). The potential phosphorylation site for the Serine/threonine protein kinases ATM/ATR/DNA-PK (S172 in dr-Neurod1) is indicated by an asterisk. The presence of a conserved S or T at aa176 in dr-Neurod1, highly suggestive of a site of phosphorylation for an unidentified serine/threonine protein kinase, is also indicated by an asterisk.

Acknowledgments

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