FIGURE 4 Conserved miRNAs are more efficiently processed and better expressed. (A) Comparing the relative Drosha cleavage efficiencies (the left panel), Dicer cleavage efficiencies (the middle panel), and mature miRNA expression (the right panel) between the conserved and unique zebrafish miRNAs (x-axes). The right panel analyzed all the miRNAs, i.e., not just the Drosha or Dicer substrates examined in this study, and the y-axis is miRNA expression values after log10 transformation (GSE57169). Averages and standard deviations are shown, the P values listed on top, and parentheses indicate the numbers of miRNAs in the categories. (B) Comparing the relative Drosha cleavage efficiencies (the left panel), Dicer cleavage efficiencies (the middle panel), and mature miRNA expression (GSE163852; the right panel) between the conserved and unique fruitfly miRNAs (x-axes). Labels are the same as in (A).
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