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Figure 7 AR is certainly correlated with Mxd3 in the male hMX3. (A) AR and Mxd3 staining in the liver tissue of hMX3 ± Dox as determined by immunohistochemical analysis. Scale bar: 100 μm. (B,C) Molecular analysis of androgen-responsive gene expression by (B) qRT-PCR and (C) western blot analysis in the male livers of WT ± Dox, gMX2 ± Dox and hMX3 ± Dox. (D) Schematic diagram of the mechanism by which Mxd3 joins the NAHCC progression of the male hMX3 + Dox zebrafish. Mxd3 mediates the androgen receptor signaling in HCC. Statistically significant differences from the controls are indicated by * (p < 0.05), and ** (p < 0.01).