ZFIN Image: Kikel-Coury et al., 2021, Fig 9

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Figure Caption

Fig 9

CNG control heart function through sympathetic/parasympathetic modulation.

(A) Schematic of sympathetic and parasympathetic regulation of cardiac function through communication with the ICNS. (B) Quantification of the number of ventricular contractions with sympathetic agonist (isoproterenol) treatment over various location ablation of nucGFP⁺ cells. (C) Quantification of the number of ventricular contractions with parasympathetic agonist (carbachol) treatment over various location ablation of nucGFP⁺ cells. (D) Quantification of percent duration of ventricular fibrillation in metrn^−/− animals after treatment with the isoproterenol or carbachol. (E) Schematic of overall findings of CNG showing that they originate from the neural crest and require metrn to generate gfap⁺ cells that control heart rate and rhythm. Data are represented as mean ± SEM. Statistics summarized in S1 Table. See S1 Data for raw data. A, atrium; ANS, autonomic nervous system; bpm, beats per minute; CNG, cardiac nexus glia; ICNS, intracardiac nervous system; OT, outflow tract; V, ventricle.

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Phenotype details

Acknowledgments

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