ZFIN Image: Xu et al., 2021, FIGURE 1

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Figure Caption

FIGURE 1

Analysis of congenital cardiomyopathy in smyd1b^sa15678 mutant using Tg(myl7:Lifeact-GFP) transgenic zebrafish model. (A–D) Morphology and Lifeact-GFP expression in the heart region of WT Tg(myl7:Lifeact-GFP)^mb21 (A,B), and smyd1b^sa15678; Tg(myl7:Lifeact-GFP)^mb21 mutant (C,D) transgenic larvae at 72 hpf. Pericardial edema is indicated by arrow in smyd1b^sa15678; Tg(myl7:Lifeact-GFP)^mb21 transgenic mutant larvae (C). Scale bars: 250 μm. (E–J) Actin think filaments in cardiomyocytes revealed by Lifeact-GFP (E,H) and phalloidin staining (F,I) in WT Tg(myl7:Lifeact-GFP)^mb21 (E–G), and smyd1b^sa15678; Tg(myl7:Lifeact-GFP)^mb21 transgenic mutant (H–J) embryos at 72 hpf. (G,J) are merged pictures of (E,F,H,I), respectively. Scale bars: 50 μm.

Acknowledgments

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