ZFIN Image: Liu et al., 2021, FIGURE 6

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Figure Caption

FIGURE 6

Increased grm5 expression level in shank3-deficient zebrafish upon early VPA treatment. (A,B) Quantitative immunoblot blot analysis showed that the expression level of neuron protein NeuN was not significantly restored in the brain of shank3ab^{– /–} zebrafish treated with VPA relative to WT zebrafish (2 mpf). Similarly, the expressions of post-synaptic homer1 protein (C,D) and presynaptic synaptophysin protein (E,F) were not significantly increased in in the brain of shank3ab^{– /–} zebrafish treated with VPA relative to WT zebrafish (2 mpf). (G) The relative mRNA expression levels of grm1a, grm1b, and grm5a at 4.5 mpf were detected. Each group n = 3. Data are shown as mean ± SEM. *P < 0.05, **P < 0.01.

Acknowledgments

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