ZFIN Image: Liu et al., 2021, FIGURE 4

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Figure Caption

FIGURE 4

shank3 deficiency resulted in the reduction of synapse-related proteins in adult zebrafish brain. (A,B) Quantitative immunoblot blot analysis showed that the neuron protein NeuN was significantly decreased (50% of WT) in the shank3ab^{– /–} male zebrafish brain relative to WT zebrafish (3.5 mpf). (C,D) The expression of post-synaptic homer1 protein was markedly reduced in shank3ab^{– /–} male zebrafish brain compared with that of WT zebrafish (3.5 mpf, 10% of WT). (E,F) The expression of presynaptic synaptophysin protein was significantly reduced in shank3ab^{– /–} male zebrafish brain compared with that of WT zebrafish (3.5 mpf, 36% of WT). N = 3 for each group. Data are presented as mean ± SEM; *P < 0.05, **P < 0.01.

Acknowledgments

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