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Figure 7
Gran1 inhibits growth of intracellular Mtb. Macrophages were infected with Mtb followed by incubation with Gran1 for 4 d. Multiplication of Mtb was determined by plating cell lysates on 7H11 agar plates. After 21 d of incubation, the number of colony-forming units (CFU) was determined. Lines indicate mean values and dots represent individual values of n-fold mycobacterial growth as compared to growth control (d4) for eleven individual donors. Statistical analysis was performed using multiple t-tests (Wilcoxon rank test, p = 0.05).
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