IMAGE

Fig. 4

ID

ZDB-IMAGE-210725-24

Genes

bbc3
pmaip1

Antibodies

Ab1-casp3

Source

Figures for Wang et al., 2021

Image

Figure Caption

Fig. 4 Loss of puma rescues mdm2-null induced apoptosis at early embryonic stage.

A Anti-active Caspase-3 staining on 12, 15, 18, and 21 hpf mdm2^+/+ and mdm2^−/− zebrafish embryos. B qRT-PCR analysis of puma and noxa in 15 hpf mdm2^+/+, mdm2 siblings (mdm2+/+ and mdm2^+/−) and mdm2^−/− zebrafish embryos. n = 3 from ~30 pooled embryos per sample. Bars represent mean ± SEM. **p < 0.01. C Anti-active Caspase-3 staining on 12, 15, 18, and 21 hpf mdm2^+/+ bbc3^−/− and mdm2^−/− bbc3^−/− zebrafish embryos. D Gross images of 15, 18, and 21 hpf mdm2^+/+, mdm2^−/−, and mdm2^−/− bbc3^−/− zebrafish embryos.

Figure Data

Expression / Labeling details

Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Cell Death Dis.