ZFIN Image: Butti et al., 2021, Fig. 3

Image

Figure Caption

Fig. 3 C9-miR zebrafish exhibited attenuated miniature endplate currents (mEPCs) at NMJs.

a Recordings of mEPCs, which result from spontaneous release of a quantum, were recorded in 6 dpf control and C9-miR fish (n = 6). b Representative mEPCs. Animals with reduced C9orf72 (C9-miR) displayed mEPCs with reduced frequency (c) (n = 6–7; ***p < 0.0001; Student’s t test) and amplitude (d) (n = 7; **p < 0.001; Student’s t test). Rise time (e) (n = 7; p = 0.3947; Student’s t test) and decay time (f) constant kinetics of mEPC (n = 7; p = 0.8385; Student’s t test) were not found to be significantly different between controls and C9-miR. Data are presented as mean ± SEM. n represents the number of fish.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Commun Biol