ZFIN Image: Crilly et al., 2021, Figure 2

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Figure 2

An example of primary analysis suggests metabolic pathways are dysregulated in leukocytes following ICH in zebrafish larvae. (A) Summary of gene expression across leukocyte samples in response to hemorrhage. Values outlined in yellow are upregulated and those outlined in blue are downregulated in hemorrhage. Values of genes expressed in neutrophils are in purple bubbles and those in macrophages are in orange bubbles. (B) Volcano plots showing the log2 fold change of gene expression in macrophages (left panel) and neutrophils (right panel) when compared to ICH– samples. Significant genes (p < 0.05, log10 > 1.3) are in red. (C) Network analysis reveals dysregulation in metabolic pathways in leukocytes following ICH. Metabolic pathways and PPAR signaling pathway pAdj = 0.004.

Acknowledgments

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