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Fig. 2 Cardioprotective effects of CA against Dox-induced cardiotoxicity in adult zebrafish. (A) Schematic of the schedule for CA administration and DOX injection. (B) High frequency echocardiography was performed at 56 days post injection to quantify cardiac functions. 0.01% DMSO was used as a control. (n = 15 per group) (C) CA treated fish showed less pathological cardiac remodeling after long-term doxorubicin treatment, examined by relative mRNA levels of nppa and nppb gene. n = 3 per group. One-way ANOVA followed by the Tukey post hoc test was used to compare multiple groups for each gene. (D) HE staining showed that CA preserved cardiomyocyte architecture. *P < 0.05, **P < 0.01.