ZFIN Image: Lai et al., 2020, Figure 2

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Figure 2

Morphometric and DNA methylation level comparison for wild types, dnmt3aa, and dnmt3ab gene knockout zebrafish. (A) Morphologies of six-month-old wild types, dnmt3aa, and dnmt3ab knockout zebrafish. Female fish is shown in the upper panel and male fish in the bottom panel. (B) Morphometric analysis of wild types, dnmt3aa, and dnmt3ab gene knockout zebrafish by principal component analysis (PCA) method. (C) Schematic diagram showing the biochemical pathway on key proteins involving cytosine DNA methylation. Comparison of 5-hmC (D), 5-mC (E), and 5-hmC/5-mC ratio (F) between wild types, dnmt3aa, and dnmt3ab knockout zebrafish. The data are expressed as the mean with S.E.M. and analyzed by one-way ANOVA followed by Fisher’s LSD post hoc test (n = 6 for wild type; n = 4 for dnmt3aa KO fish; n = 5 for dnmt3ab KO fish).

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Phenotype details

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Genes (Basel)