ZFIN Image: Beckwith-Cohen et al., 2020, Figure 4.

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Figure Caption

Figure 4.

Chemogenetic manipulation of HCs modulates the bipolar cell light response. Application of FMRFamide had no effect on the ERG of WT zebrafish (A), but decreased the maximal b-wave amplitude in FaNaC zebrafish (B), reaching a maximum ∼40% decrease in the b-wave (C). Application of the buffer HEPES (pH 7.35) cancelled the effects of FMRFamide (C). FMRFamide response was dose dependent having an EC₅₀ of 4.25 μm (D). Application of the agonist PSEM^89S (30 μm) also caused a decrease in the maximal b-wave amplitude, but to a lesser degree (E, F).

Acknowledgments

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