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Fig. 8 Effects of amh and gdf9 double mutations (amh−/−;gdf9−/−) on gonadal development at 3 mpf (90 dpf). (A) Ovaries of different genotypes. While amh mutation had no effect on PG-PV transition despite increased PG follicles, the mutation of gdf9 completely blocked the transition with all follicles arrested at PG stage. Double mutation of the two genes (amh−/−;gdf9−/−) resulted in enlarged ovaries full of PG follicles only. (B) Testes of different genotypes. The mutation of gdf9 (amh−/−;gdf9−/−) had no effect on testis hypergrowth and dysfunctional spermatogenesis induced by amh single mutation (amh−/−;gdf9+/−). PG, primary growth follicles; PV, pre-vitellogenetic follicles; SG, spermatogonia in cysts; SC, spermatocytes; SZ, spermatozoa.
Reprinted from Molecular and Cellular Endocrinology, 517, Zhang, Z., Zhu, B., Chen, W., Ge, W., Anti-Müllerian hormone (Amh/amh) plays dual roles in maintaining gonadal homeostasis and gametogenesis in zebrafish, 110963, Copyright (2020) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.