ZFIN Image: Zhang et al., 2020, Fig. 6

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Figure Caption

Fig. 6 Evidence for the involvement of gonadal inhibin in the reduced expression of fshb in the pituitaries of amh mutants. (A) Expression of inha in the ovary and testis of control (amh+/−) and amh mutant (amh−/−) at 4 mpf. The copy numbers of target transcripts (amh and ef1a) were determined by q-PCR with standard curves. The abundance of inha was expressed either as the ratio to that of the housekeeping gene ef1a (upper) or the total amount per gonad (lower). *** P < 0.001 (n = 6). (B) Restored expression of fshb in the double mutant amh−/−;inha−/− at 6 mpf in both females (upper) and males (lower). Different letters indicate statistical significance. (C) Histological examination of the ovaries (upper) and testes (lower) of the amh−/−;inha−/− double mutant at 6 mpf.

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Acknowledgments

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Reprinted from Molecular and Cellular Endocrinology, 517, Zhang, Z., Zhu, B., Chen, W., Ge, W., Anti-Müllerian hormone (Amh/amh) plays dual roles in maintaining gonadal homeostasis and gametogenesis in zebrafish, 110963, Copyright (2020) with permission from Elsevier. Full text @ Mol. Cell. Endocrinol.