ZFIN Image: Barske et al., 2020, Fig. 6

Image

Figure Caption

Fig. 6 Model of Pou3f3 regulation in the evolution of vertebrate gill covers. Pou3 genes are ancestrally expressed in the CNS (blue element). In early jawed vertebrates, emergence of a new enhancer in the Pou3f3 locus (green element) allowed cooption of its expression into arch mesenchyme. Subsequent sequence changes in this enhancer then reinforced anterior arch expression in bony vertebrates and pan-arch expression in cartilaginous vertebrates. Additional enhancers (e.g. yellow element) likely evolved to reinforce arch expression, at least in the teleost lineage. Intersection of these patterns with PEM signaling centers produces the single- versus multiple gill cover patterns observed in the two gnathostome lineages today.

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ Proc. Natl. Acad. Sci. USA