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Fig. 5 Development of camk2g1 mutants injected with camk2g1 MO. Control, camk2g1 morphants, camk2g1 mutants, and camk2g1 mutants injected with the camk2g1 MO were imaged at 48hpf (A-L). Camk2g1 morphants display curved tails (D) smaller otoliths (E) and defects in cloacal morphology (F). Control embryos, camk2g1 mutants, and camk2g1 mutants injected with the camk2g1 MO do not display such morphological defects. CaMKII activity assays of 72hpf embryos reveal up to twice the reduction in CaMKII activity in camk2g1 morphants in a dose-dependent manner, when compared to camk2g1 mutants (M).
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Reprinted from Gene, 742, Rothschild, S.C., Ingram, S.R., Lu, F.I., Thisse, B., Thisse, C., Parkerson, J.A., Tombes, R.M., Genetic compensation of γ CaMKII, an evolutionarily conserved gene, 144567, Copyright (2020) with permission from Elsevier. Full text @ Gene