Fig 4

Fig 4

Slc25a46^238s zebrafish show a number of differentially expressed genes based on mRNA sequencing data: (A) Heat maps of all genes mapped to zebrafish genome comparing slc25a46^238s mutant to Cas9 control and slc25a46 F0 CRISPR; (B) Volcano plots showing differentially expressed genes between slc25a46^238s mutant versus Cas9 control or slc25a46 F0 compared to Slc25a46 F0 versus Cas9 control. Points above the red dashed line represent differentially expressed genes with p≤0.01; Red points represent chosen top genes of interest; (C) Upset plot showing intersections of upregulated and downregulated genes common (connected dots) and uniquely differentially expressed (individual dots) in slc25a46^238s mutant vs slc25a46 F0 and Cas9 control. The plot is based on the genes with p≤0.01.