Figure 4

Figure 4

Transcriptomic changes detected in old wildtype, young mutant, and old mutant telencephali. (a) Normalised gene counts of grna and grnb in young and old wildtype animals. **** padj ≤ 0.0001, each data point represents a distinct biological replicate (five telencephali per group were analysed). (b) Volcano plot of DEGs in old wildtype animals (young wildtype animals were used as a reference) (padj ≤ 0.05; 1 ≤ log2FC ≤ −1). (c) Volcano plot of DEGs in young mutant animals (young wildtype animals were used as a reference) (padj ≤ 0.05; 1 ≤ log2FC ≤ −1). (d) Volcano plot of DEGs in old wildtype animals (young mutant animals were used as a reference) (padj ≤ 0.05; 1 ≤ log2FC ≤ −1). (e) Volcano plot of DEGs in old mutant animals (young mutant animals were used as a reference) (padj ≤ 0.05; 1 ≤ log2FC ≤ −1).