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Fig. S5
EGFP+ HSPCs in asxl1 +/+, asxl1 +/- and asxl1 -/- embryos at 3 dpf. Knockdown of bim (D-F) and bid (G-I) or overexpression of bcl2 (J-L) each were able to partially rescue HSPC numbers in asxl1 -/- embryos compared with control embryos. This result is expected because mitochondrial intrinsic programmed cell death depends on the combined activities of BH3-only pro-apoptotic proteins and is blocked by prosurvival proteins like bcl2.
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Full text @ Dis. Model. Mech.