ZFIN Image: Ki et al., 2019, Figure 9

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Figure Caption

Figure 9 Working model

Overall proposed model for CEP41‐mediated angiogenesis via endothelial cilia. (1) Potential interactions of CEP41 with MAP and/or polyglutamylase and their transportation from the centrosome to the cilium, (2) tubulin glutamylation in endothelial cilia by fluid flow‐driven shear stress or hypoxia, (3) activation of AURKA dependent on CEP41 under shear stress or hypoxia, (4) induction of cilia disassembly via AURKA activation, and (5) upregulation of pro‐angiogenic regulators, such as VEGFA and VEGFR2.

Acknowledgments

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