ZFIN Image: Chen et al., 2020, Figure 2

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Figure 2

Effects of berberine (BBR) on hepatic steatosis in high-cholesterol diet (HCD)-induced zebrafish larvae. (A) The zebrafish larvae were treated with the control diet, HCD diet, and HCD plus BBR (5 μM) treatment. Hepatic steatosis was observed by whole-body Oil Red O (ORO) staining (line 1, refer to the black dotted, bar = 100 μm), H&E staining (line 2, refer to the yellow dotted, bar = 100 μm), and TEM (line 3, bar = 2μm; line 4, bar = 1 μm). m mitochondrion, n cell nucleus, LD lipid droplet. (B) L-plastin-labeled macrophages in Tg (fabp10a: dsRed) zebrafish. The statistical results of the positive area of ORO staining were shown in (C) and the quantity of macrophage in the liver of larval zebrafish in (D). Effects of BBR on the levels of triglyceride (E), glucose (F), and cholesterol (G) in livers of zebrafish larvae fed with HCD. ^#Compared with the HCD group, P < 0.05.

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Acknowledgments

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