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Fig 1
The M-line of the sarcomere diagraming the protein interactions between myosin thick filaments. The physical protein interactions through the M-line between antiparallel thick filaments are demonstrated by solid lines for one connection and faded dotted lines for the other connection between antiparallel thick filaments. Myosin and titin are incorporated into the M-line around the same time. This work suggests that myomesin is added next and requires both titin and myosin to be present for myomesin to be incorporated. Titin and myomesin together recruit obscurin, or obscurin-like 1, to the M-line [
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