ZFIN Image: Liao et al., 2019, Fig. 4.

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Figure Caption

Fig. 4.

Valproic acid (VPA) treatment alleviates the movement phenotype and neuronal hyperexcitability of gabrg2^−/−larvae. (A) Quantification of the maximum acceleration upon light stimulus before and after an acute VPA treatment of 200 µM for 2 h, showing the alleviating effect of VPA. (****P<0.0001, unpaired t-test.) (B) Representative swimming tracks (15 s following photic stimulus) showing that VPA exposure prevent the whirlpool behavior of gabrg2^−/− (5 dpf). (C,D) Calcium imaging and fluorescence quantification from gabrg2-KO Tg(neurod:GCaMP6f) larvae (5 dpf), showing that the neuronal hyperexcitability is relieved after VPA treatment (200 µM for 2 h). ot, optic tectum; cb, cerebellum. (****P<0.0001, ***P<0.001, **P<0.01, *P<0.05, two-way ANOVA).

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Acknowledgments

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