ZFIN Image: Collodet et al., 2019, Figure 3

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Figure Caption

Figure 3

Transcriptome data analysis of the AMPK-activation response following treatment with 991 and AICAR. Venn diagrams showing the transcriptome profiling specificity of 991 and AICAR in MEFs (A) and mouse primary hepatocytes (B). Two-way ANOVA with Benjamini and Hochberg multiple testing correction was applied to discriminate 991 vs. control and AICAR vs. control conditions. The moderated significance value was set at P < 0.05 for the interaction between the genetic background and treatment, as well as for the pairwise comparisons, and a fold-change cutoff of 1.3 was applied. Each group of transcripts is shown with a color code, as specified in the figure. The numbers correspond to the numbers of transcripts altered and the percentage contribution to the total number of transcripts identified for each treatment, respectively. The surface of each circle is proportional to the total number of transcripts it contains.

Acknowledgments

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