ZFIN Image: Gómez-Abenza et al., 2019, Fig. 4

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Figure Caption

Fig. 4

Spint1a deficiency is required at cell autonomous and non-autonomous levels to enhance SKCM cell dissemination in a zebrafish larval allotrasplantation model. Analysis of dissemination of control and Spint1a-deficient SKCM allotransplants in wild type larvae (a-d) and SKCM allotransplants in wild type and Spint1a-deficient larvae (e-h). a and e Experimental design. b and f Representative images (overlay of bright field and red channels) of SKCM invasion at 5 dpi. Bars: 500 μm. c and g Percentage of invaded larvae for both tumor genotypes. Each dot represents a single tumor and the mean ± SEM is also shown. **p < 0.01, ***p < 0.0001 according to unpaired Student t test. d and h Number of tumor foci per larva. ***p < 0.0001 according to Chi-square Tests

Acknowledgments

This image is the copyrighted work of the attributed author or publisher, and ZFIN has permission only to display this image to its users. Additional permissions should be obtained from the applicable author or publisher of the image. Full text @ J. Exp. Clin. Cancer Res.