ZFIN Image: Vetrivel et al., 2019, Fig. 9

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Figure Caption

Fig. 9

Disappearing lens vesicle and Ap2α in lens and retina. The apoptotic marker Cleaved Caspase 3 (green) was used to characterize apoptotic events during ocular development from E11.5 -E13.5, when the lens structure diminishes. The arrows marking the mutant lens at E11.5-E12.5 clearly indicate that the apoptotic death of the lens structure. The ocular transcription factor Ap2α (red) was used to characterize transcriptional regulation of ocular development from E11.5 -E13.5, when the lens structure diminishes. The apoptotic process leads to a shrinking lens as it can be observed from the decreased number of Ap2α-positive cells in the subsequent stages. The bars indicate 50 μm.

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Reprinted from Experimental Eye Research, 188, Vetrivel, S., Tiso, N., Kügler, A., Irmler, M., Horsch, M., Beckers, J., Hladik, D., Giesert, F., Gailus-Durner, V., Fuchs, H., Sabrautzki, S., German Mouse Clinic, Helmholtz Zentrum München, German Research Center for Environmental Health GmbH, Neuherberg, Germany, Adler, T., Treise, I., Busch, D.H., Aguilar-Pimentel, A., Ollert, M., Götz, A., Amarie, O.V., Stoeger, T., Schulz, H., Becker, L., Klopstock, T., Schrewe, A., Spielmann, N., Bekeredjian, R., Garrett, L., Hölter, S.M., Zimprich, A., Wurst, W., Mayer-Kuckuk, P., Hans, W., Rozman, J., Klingenspor, M., Neff, F., da Silva-Buttkus, P., Calzada-Wack, J., Rácz, I., Zimmer, A., Rathkolb, B., Wolf, E., Prehn, C., Adamski, J., Östereicher, M., Miller, G., Steinkamp, R., Lengger, C., Maier, H., Stoeger, C., Leuchtenberger, S., Gailus-Durner, V., Fuchs, H., Hrabě de Angelis, M., Hrabě de Angelis, M., Graw, J., Mutation in the mouse histone gene Hist2h3c1 leads to degeneration of the lens vesicle and severe microphthalmia, 107632, Copyright (2019) with permission from Elsevier. Full text @ Exp. Eye. Res.